发明名称 A METHOD FOR THE PREPARATION OF 3-AMINO-N-CYCLOPROPYL-2-HYDROXYL-HEXANAMIDE
摘要 <p>The present invention discloses a method for preparing 3-amino-N-cyclopropyl-2-hydroxyl-hexanamide. The invention relates to the technical field of the preparation of pharmaceutical intermediates. The method uses trans-2-hexenoic acid as the starting material, through the steps of epoxidation, ring-opening by nitrile, amidation, etc., to obtain the final product 3-amino-N-cyclopropyl-2-hydroxyl-hexanamide. The method uses easily-obtainable materials, requires mild reactive conditions, and adopts stable processes. Therefore it is suitable for large scale industrial production.</p>
申请公布号 WO2013186248(A1) 申请公布日期 2013.12.19
申请号 WO2013EP62121 申请日期 2013.06.12
申请人 JANSSEN PHARMACEUTICA NV 发明人 LIN, BANGPING;WANG, ZHONGMEI;GUO, BIN
分类号 C07C231/02 主分类号 C07C231/02
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