| 摘要 |
The present invention relates to a pharmaceutical composition for preventing or treating fracture or osteoporosis, comprising, as an active ingredient, a gene selected from a group consisting of slit1, slit2, slit3, robo1, robo2 and vilse, or an expressed protein of the gene. The present invention also relates to a marker composition for predicting the risk of fracture or osteoporosis, which comprises the protein, to a kit for predicting the risk of fracture or osteoporosis, which comprises an antibody that specifically binds to the protein, and to an information provision method for predicting the risk of fracture or osteoporosis, comprising a step of measuring the level of expression of the slit protein by means of an antigen-antibody binding reaction using an antibody that specifically binds to the protein. The slit 3 of the present invention may increase bone formation and decrease bone reabsorption in a cell and animal model, and has a negative correlation with the incidence rate of osteoporosis, and therefore, can be used effectively as a composition for preventing or treating fracture or osteoporosis and as a bio marker for prediction of the risk of fracture or osteoporosis. |
