发明名称 |
MARKER FOR DETERMINING THE THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELLS, AN INHIBITOR OF THE MARKER FOR THERAPEUTIC USE AND STEM CELLS WITH LOW EXPRESSION OF THE MARKER FOR THERAPEUTIC USE |
摘要 |
<p>The invention relates to methods for determining the therapeutic potential and immunoregulatory capacity of stems cells, based on expression levels of microRNA miR-335. This determination can be used as a criterion for the release of groups of stem cells for therapeutic use. In addition, the invention also relates to in vitro methods for increasing the immunoregulatory capacity of a stem cell, in which said methods comprise treating the stem cell with an miR-335 inhibitor. Finally, the invention relates to therapeutic methods and uses for treating a patient with an autoimmune disease, an inflammatory disease, graft-versus-host disease or a disease requiring transplant tolerance induction or regeneration and/or repair of tissue, said therapeutic methods and uses comprising the administration of a stem cell having reduced miR-335 levels of expression and/or activity.</p> |
申请公布号 |
WO2013186418(A1) |
申请公布日期 |
2013.12.19 |
申请号 |
WO2013ES70381 |
申请日期 |
2013.06.12 |
申请人 |
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III |
发明人 |
GONZALEZ DE LA PENA, MANUEL ANGEL;BERNAD MIANA, ANTONIO;TOME PIZARRO, MARIA |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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