COMPOSITIONS AND METHODS FOR TRANSMUCOSAL ABSORPTION

摘要

The invention provides compositions and methods for administering therapeutic compounds, specifically cyclobenzaprine or amitryptyline, for transmucosal absorption, wherein the compositions contain a basifying agent in addition to the therapeutic agent. The compositions and methods have a number of surprising pharmacokinetic benefits over oral administration. Methods of treating fibromyalgia in a human subject are also provided.