| 摘要 |
The present invention relates to an optical activity axially chiral alpha-allenic alcohol, a synthesis method and use thereof. A method of preparing a high optical activity chiral alpha-allenic alcohol by using propargyl alcohol, aldehyde and chiral alpha,alpha-diphenyl-L-prolinol under the protection of tert-butyldimethylsilyl with an accelerant zinc bromide. The axially chiral alpha-allenic alcohol has the structural formula (I). The method of the present invention has the following advantages: the synthesis route is short, operations are simple, raw materials are readily available, separation and purification are convenient, the substrate has high universality, the total yield is high, and enantioselectivity and diastereoselectivity are high. The high optical activity axially chiral alpha-allenic alcohol synthesized by adopting the method of the present invention can conveniently synthize 2,5-dihydrofuran compounds having central chirality and complete chirality, and at the same time can further synthesize axially chiral allenic amine and allenic malonic ester compounds having complete chirality. |
