发明名称 |
COMPOUNDS FOR TREATMENT OF HEART FAILURE |
摘要 |
A combination of: a first tetracycline (TC) component; and a second component capable of releasing nitric oxide (NO) or a nitrate capable of mimicking NO effects in vivo (NO mimetic). The combinations of the invention advantageously act as more effective MMP modulators with selective reductions in circulating MMP-9 levels in-vivo and inhibitory effects on MMP-2 and MMP-9 levels in-vitro. The combinations of the invention also advantageously act as modulators of inflammation mediators. The co-existence of abnormalities of MMP enzymes and inflammation in many diseases make these characteristics advantageous. Therefore, the various combinations of the invention find utility in medical applications where MMPs and/or inflammation is implicated. |
申请公布号 |
US2013338118(A1) |
申请公布日期 |
2013.12.19 |
申请号 |
US201113992663 |
申请日期 |
2011.12.08 |
申请人 |
GILMER JOHN;LEDWIDGE MARK;MCDONALD KEN;O'FLYNN PAT;SOLVOTRIN INNOVATIONS LIMITED |
发明人 |
GILMER JOHN;LEDWIDGE MARK;MCDONALD KEN;O'FLYNN PAT |
分类号 |
A61K47/48;A61K45/06 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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