Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids

摘要

The present invention concerns a conjugated compound of formula Q-Z-R 4 wherein Q is a TLR7 and/or TLR8 agonist and Z-R 4 is a lipid covalently linked to an amino acid or peptide coupled to a polyamine group, and a process for the manufacture of said conjugated compound, as well as a complex formed between said conjugated compound and a polyanionic molecule and a pharmaceutical composition containing said conjugated compound or complex. The invention further concerns the use of said conjugated compound or complex in the treatment of infection, cancer or immune disorders or for use in vaccines.