发明名称 |
Therapeutic target for periodontal disease. |
摘要 |
<p>A marker for determining the onset of periodontal disease and a marker for determining the progression stage of periodontal disease, each containing autoinducer-2. A screening method for identifying improving agents or preventive agents for periodontal disease using autoinducer-2 as screening target has been disclosed. 4-bromo-5-(4-methoxyphenyl)-2(5H)-Furanone, 3,4-dibromo-5-hydroxy-2(5H)-Furanone, 4-bromo-5-methoxy-5-(4-methoxyphenyl)-2(5H)-Furanone and 4-[[3-bromo-2,5-dihydro-2-(4-methoxyphenyl)-5-oxo-2-furanyl]oxy]-Benzoic acid have been described as medicaments and are useful for treating periodontal disease.</p> |
申请公布号 |
EP2631648(A3) |
申请公布日期 |
2013.12.18 |
申请号 |
EP20130163479 |
申请日期 |
2010.04.15 |
申请人 |
KAO CORPORATION |
发明人 |
SOUNO, HATSUMI;FUJINAKA, HIDETAKE;NAKAMURA, JUNJI |
分类号 |
G01N33/50;A61K31/34;A61K31/341;C07H23/00;C12Q1/02;C12Q1/18 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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