发明名称 |
ANTI-VEGF ANTIBODIES AND USES THEREOF |
摘要 |
Provided are monoclonal antibodies and antigen binding fragments thereof that specifically bind vascular endothelial growth factor (VEGF). The anti-VEGF monoclonal antibodies block VEGF binding to its receptors (e.g., VEGFR1 and/or VEGFR2) and prevent phosphorylation of VEGFR2 by VEGF. Also provided are methods of using the monoclonal anti-VEGF antibodies for treatment of disease, including cancer. |
申请公布号 |
EP2579895(A4) |
申请公布日期 |
2013.12.18 |
申请号 |
EP20110796306 |
申请日期 |
2011.06.14 |
申请人 |
VACCINEX, INC. |
发明人 |
CROY, LESLIE A.;PARIS, MARK J.;SMITH, ERNEST S. |
分类号 |
A61K39/395;C07K16/22 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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