发明名称 |
Immobilized bioactive hydrogel matrices as surface coatings |
摘要 |
The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate. |
申请公布号 |
US8609122(B2) |
申请公布日期 |
2013.12.17 |
申请号 |
US20070937851 |
申请日期 |
2007.11.09 |
申请人 |
LAMBERTI FRANCIS V.;KLANN RICHARD CHRIS;HILL RONALD STEWART;PIONEER SURGICAL TECHNOLOGY, INC. |
发明人 |
LAMBERTI FRANCIS V.;KLANN RICHARD CHRIS;HILL RONALD STEWART |
分类号 |
A61F13/00;A61L27/00;A61L27/26;A61L27/34;A61L27/52;A61L29/00;A61L31/00;A61L31/10;B32B19/00;B32B27/00;C07K14/78 |
主分类号 |
A61F13/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|