发明名称 |
Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
摘要 |
The present invention relates to compounds defined by formula (I) wherein the groups R1 and R2 are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 beta-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia. |
申请公布号 |
US8609690(B2) |
申请公布日期 |
2013.12.17 |
申请号 |
US200913059233 |
申请日期 |
2009.08.21 |
申请人 |
ECKHARDT MATTHIAS;HAMILTON BRADFORD S.;HIMMELSBACH FRANK;PETERS STEFAN;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
ECKHARDT MATTHIAS;HAMILTON BRADFORD S.;HIMMELSBACH FRANK;PETERS STEFAN |
分类号 |
A61K31/541;A61K31/46;A61K31/498;A61K31/519;C07D451/02 |
主分类号 |
A61K31/541 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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