发明名称 COMPOSTO, COMPOSIÇÃO FARMACÊUTICA QUE O CONTÉM E USO DO COMPOSTO
摘要 The invention relates to novel chimeric antibiotics of formula (I) wherein R<SUP>1</SUP> represents OH, OPO<SUB>3</SUB>H<SUB>2</SUB> or OCOR<SUP>5</SUP>; R<SUP>2</SUP> represents H, OH or OPO<SUB>3</SUB>H<SUB>2</SUB>; A represents N or CR<SUP>6</SUP>; R<SUP>3 </SUP> represents H or fluorine; R<SUP>4</SUP> is H, (C<SUB>1</SUB>-C<SUB>3</SUB>) alkyl, or cycloalkyl; R<SUP>5</SUP> is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; R<SUP>6</SUP> represents H, alkoxy or halogen; and n is O or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula (I). These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).
申请公布号 BRPI0718862(A2) 申请公布日期 2013.12.17
申请号 BR2007PI18862 申请日期 2007.11.09
申请人 ACTELION PHARMACEUTICALS LTD 发明人 CHRISTIAN HUBSCHWERLEN;PHILIPPE PANCHAUD;JEAN-LUC SPECKLIN
分类号 C07D413/14;A61K31/4375;A61K31/4709;A61P31/00;C07D471/04 主分类号 C07D413/14
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