发明名称 |
Short Interfering RNA (siRNA) Analogues |
摘要 |
The present invention is directed to double-stranded short interfering (siRNA) analogues comprising locked nucleic acid (LNA) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). The compounds disclosed herein has improved properties compared to non-modified siRNAs and may, accordingly, be useful as therapeutic agents, e.g., in the treatment of various cancer forms. More particularly, the present invention is directed to siRNA analogues comprising a sense strand and an antisense strand, wherein each strand comprises 12-35 nucleotides and wherein the siRNA analogues comprise at least one locked nucleic acid (LNA) monomer. |
申请公布号 |
DK1606406(T4) |
申请公布日期 |
2013.12.16 |
申请号 |
DK20040722233T |
申请日期 |
2004.03.22 |
申请人 |
SANTARIS PHARMA A/S |
发明人 |
ELMEN, JOACIM;KOCH, TROELS;SOERENSEN, ANDERS, MALLING;OERUM, HENRIK;WAHLESTEDT, CLAES;LIANG, ZICAI |
分类号 |
C12N15/11;A61K31/713;A61K38/00;A61P35/00;C07H21/04;C12N15/113 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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