Cytotoksiske midler, der omfatter nye tomaymycinderivater, og terapeutisk anvendelse deraf

摘要

The present invention is related to new tomaymycin derivatives having a linking chain between two units of pyrrolo[2,1c][1,4]benzodiazepines, substituted by a non-cleavable linker and their conjugated to cell binding agents, their process of preparation and their therapeutic uses.