| 摘要 |
The present invention is directed to a titration method for cytopathogenic agent, particularly infectious viruses. In particular, the present invention is based on a new method for in vitro determining the titre of infectious agent, such as viruses in solution by comparing the viability of the infected cells (in monolayer conformation or in suspension) against a standard curve obtained by measuring the cell viability of infected host cells cultured in monolayer or in suspension with a known cytopathogenic agent stock. The invention is of special utility in the pharmaceutical industry for cytopathogenic agent clearance studies and for the identification and optimization of antiviral compounds involved in drug development and/or in pharmaceutical compositions. |
