METHOD FOR PREPARING ARTEMISININ BY ARTEMISINIC ACID

摘要

Disclosed is a method for preparing artemisinin by artemisinic acid. First, under the effect of a reducing agent such as sodium borohydride/nickel chloride or a hydrogen/metal catalyst, dihydroartemisinic acid is obtained from the artemisinic acid. Then, the dihydroartemisinic acid is oxidized into peroxided dihydroartemisinic acid by peroxide in the presence of the catalyst. Finally, the target product artemisinin can be obtained with high yield under the catalyzing of the acid and the effect of oxygen. Alternatively, a dihydroartemisinic acid derivative is obtained by protecting carboxyl by the dihydroartemisinic acid, it is oxidized into a corresponding peroxided dihydroartemisinic acid derivative by the peroxide in the presence of the catalyst, and then, the target product artemisinin can be obtained with high yield under the catalyzing of the acid and the effect of oxygen. Compared with the prior art, the present invention has the following advantages that: the used agent is cheap and is easy to be obtained, a synthetic route is short, the reaction selectivity is high, the preparation process is environmental-friendly, an operation and post-processing are simple, the total yield is high, and it is suitable for industrial production.