发明名称 |
CHIMERIC FIBROBLAST GROWTH FACTOR 23 PROTEINS AND METHODS OF USE |
摘要 |
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor ("FGF") and the C-terminus includes a C-terminal portion of an FGF23 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from a disorder, and methods of screening for compounds with enhanced binding affinity for the alphaKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. |
申请公布号 |
US2013331325(A1) |
申请公布日期 |
2013.12.12 |
申请号 |
US201313839051 |
申请日期 |
2013.03.15 |
申请人 |
MOHAMMADI MOOSA;GOETZ REGINA;NEW YORK UNIVERSITY |
发明人 |
MOHAMMADI MOOSA;GOETZ REGINA |
分类号 |
C07K14/50;A61K38/18;A61K45/06 |
主分类号 |
C07K14/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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