| 发明名称 |
Antibodies to human programmed death receptor PD-1 |
| 摘要 |
<p>Antibodies which block the binding of human Programmed Death Receptor l(hPD-l) to its ligands (hPD-Ll or hPD-L2) and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune response through the PD-I pathway is also disclosed.</p> |
| 申请公布号 |
AU2008266951(B2) |
申请公布日期 |
2013.12.12 |
| 申请号 |
AU20080266951 |
申请日期 |
2008.06.13 |
| 申请人 |
MERCK SHARP & DOHME B.V. |
发明人 |
VAN EENENNAAM, HANS;DULOS, GRADUS JOHANNES;CARVEN, GREGORY JOHN |
| 分类号 |
C07K16/28;A61K39/395;A61P35/00 |
主分类号 |
C07K16/28 |
| 代理机构 |
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