NOVEL VACCINE AGAINST MULTIPLE SUBTYPES OF INFLUENZA VIRUS

摘要

PROBLEM TO BE SOLVED: To provide a DNA plasmid capable of expressing a consensus influenza antigen in a cell of a mammal.SOLUTION: A plasmid comprises: an encoding sequence comprising consensus hemagglutinin (HA), neuraminidase (NA), M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof; a promoter operably linked to the encoding sequence that regulates expression of the consensus influenza antigen. In one aspect, the DNA plasmid further comprises an IgG leader sequence attached to an N-terminal end of the encoding sequence and operably linked to the promoter.