| 发明名称 |
MODIFIED VARIABLE DOMAIN MOLECULES AND METHODS FOR PRODUCING AND USING SAME |
| 摘要 |
The present disclosure provides an isolated protein comprising an antibody heavy chain variable region (VH) comprising a negatively charged amino acid at position 28 and/or 31 and/or 32 and/or 33 and/or 35 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen. |
| 申请公布号 |
EP2470565(A4) |
申请公布日期 |
2013.12.11 |
| 申请号 |
EP20100824324 |
申请日期 |
2010.10.25 |
| 申请人 |
GARVAN INSTITUTE OF MEDICAL RESEARCH |
发明人 |
CHRIST, DANIEL;DUDGEON, KIP |
| 分类号 |
C07K16/18;A61K39/395;C40B40/10 |
主分类号 |
C07K16/18 |
| 代理机构 |
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代理人 |
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