<p>The present invention is directed to 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.</p>
申请公布号
EP2579717(A4)
申请公布日期
2013.12.11
申请号
EP20110792940
申请日期
2011.06.06
申请人
MERCK SHARP & DOHME CORP.
发明人
ARRINGTON, KENNETH, L.;DUDKIN, VADIM;LAYTON, MARK, E.;PERO, JOSEPH, E.;REIF, ALEXANDER, J.