| 摘要 |
<p>Provided is a production process in which an optically active oxazoline is synthesized from an optically inactive compound as a starting compound with fewer production steps. In particular, provided is a process for producing an optically active compound represented by Formula (3):
(wherein R 1 is an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, and any hydrogen atom of R 1 may be replaced with a substituent; R 2 is a hydrogen atom or a group which is not reactive in the reaction below; and * represents a chiral center) or a salt thereof by subjecting a compound represented by Formula (1):
(wherein R 1 and R 2 have the same meanings as defined in Formula (3)) to a ring closure reaction in the presence of a chiral ligand having 1 or more coordination sites, a Lewis acid represented by Formula (2):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ MmZn €ƒ€ƒ€ƒ€ƒ€ƒ(2)
(wherein M is a metal ion, Z is a counter anion of M, and m and n are integers of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group.</p> |
