Lipophosphonoxins, method of their preparation and use

摘要

The invention discloses lipophosphonoxins of general formula I, wherein R 1 is (C 8 -C 22 )alkyl or hexadecyloxypropyl, tetradecyloxypropyl, tetradecyloxyethyl or hexadecyloxyethyl and R 2 is uracil, thymin or cytosin, R 3 is selected from group comprising compounds of general formula II and III, where R 4 is H or CH 2 OH, R 5 is H or OH, R 6 is H or OH, R 7 is H or CH 2 OH, R 8 is H or CH 2 OH, R 9 is H or OH, R 10 is H or OH, R 11 is H or OH, R 12 is H or CH 2 OH. Described are also diastereomers and mixtures of diastereomers of compounds of general formula I as well as corresponding pharmaceutically acceptable salts and hydrates and also a suitable method of preparation of such compounds. All described compounds of general formula I can be used as antibacterial agents or as active components of disinfectants and/or of selective in vitro growth media.