发明名称 |
Compositions and methods for treating cancer |
摘要 |
The invention provides a protected anti-neoplastic agent of the formula Hyp-N, wherein N is an anti-neoplastic agent and a protectable hydroxyl group of the anti-neoplastic is substituted with Hyp; Hyp is a moiety having the formula:
wherein
R 2 is hydrogen;
R 3 is hydrogen or C 1 -C 6 alkyl;
R 1 is C 1 -C 6 alkyl or C 1 -C 6 alkoxy, optionally substituted with one or more heteroatom-containing groups; and
R 4 is hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy, optionally substituted with one or more heteroatom-containing groups. |
申请公布号 |
EP2671581(A2) |
申请公布日期 |
2013.12.11 |
申请号 |
EP20130178249 |
申请日期 |
2004.03.29 |
申请人 |
THRESHOLD PHARMACEUTICALS, INC. |
发明人 |
MATTEUCCI, MARK;RAO, PHOTON;DUAN, JIAN-XIN |
分类号 |
A61K31/415;A61K;A61K31/4166;A61K31/44;A61K31/5377;A61K47/48;A61P35/00;C07D233/02;C07D401/00 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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