发明名称 |
METHOD OF TREATING KELOIDS OR HYPERTROPHIC SCARS USING ANTISENSE COMPOUNDS TARGETING CONNECTIVE TISSUE GROWTH FACTOR (CTGF) |
摘要 |
This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described. |
申请公布号 |
EP2670411(A1) |
申请公布日期 |
2013.12.11 |
申请号 |
EP20120742348 |
申请日期 |
2012.02.02 |
申请人 |
EXCALIARD PHARMACEUTICALS, INC. |
发明人 |
DEAN, NICHOLAS, M.;KROCHMAL, LINCOLN;HARDEE, GREGORY;FOULKES, J., GORDON;O'DONNELL, NIALL;YOUNG, LEROY;JEWELL, MARK |
分类号 |
A61K31/7088;A61K31/712;A61K45/06;A61P17/02 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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