TGF-beta receptor inhibitors to enhance direct reprogramming

摘要

In general, iPS cells are produced by delivery of stem cell-associated genes into adult somatic cells (e.g., fibroblasts). Described herein are methods for enhancing the efficiency and rate of induced pluripotent stem cell production by treating somatic cells with a transforming growth factor-beta receptor (TGFbetaR) inhibitor. Also described herein are iPS cell compositions made according to the methods described herein and iPS cell compositions comprising an iPS cell in an admixture with a TGFbetaR inhibitor. Further described herein are kits for producing iPS cells using a TGFbetaR inhibitor.