| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry, and represents a local skin composition which is an oil-in-water-in-oil emulsion containing a water phase with a dispersed lipophilic phase containing calcipotriol or monohydrate in the dissolved form; a non-ionic surfactant specified in a group consisting of polyethylene glycol glycerides and Cfatty acids, polyoxyethylene Calkyl ethers or polysorbates and a lower alkanol as a co-solvent; the above water phase is dispersed in a pharmaceutically acceptable anhydrous lipophilic carrier or base.EFFECT: invention provides the effective dissolution of calcipotriol with the lower content of a lower alcohol, as well as the good penetration of calcipotriol into the viable skin layers, higher biological activity and less skin irritation.26 cl, 5 ex, 7 tbl, 6 dwg |
