摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: what is presented is a cardioprotective agent of echinochrome -2,3,5,6,8-pentahydroxy-7-ethyl-1,4-naphthoquinone prepared either of a natural source (sea biscuits), or synthetically, differing by the fact that it represents an aqueous solution of echinochrome in the molecularly encapsulated form, as a water-soluble associate with a diphilic surfactant having a hydrophilic-lipophilic balance within the range of 12-18, and a method for preparing it. It has been shown that the molecular associates prepared by the above method are freely water-soluble and form stable solutions. The pre-set cardioprotector content is ensured by concentration of the initial working associate solution.EFFECT: invention enables making the cardioprotective aqueous preparations of echinochrome in the form of the concentrated solutions or water-soluble ointment and tableted drug products, as well as the complex preparations ensured by the enrichment with the additional components via the hydrophobic and/or aqueous phase, thereby improving their bioavailability and bioefficacy.13 cl, 8 ex |