发明名称 |
Cytoskeletal active rho kinase inhibitor compounds, composition and use |
摘要 |
The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions. |
申请公布号 |
US8604205(B2) |
申请公布日期 |
2013.12.10 |
申请号 |
US201213614641 |
申请日期 |
2012.09.13 |
申请人 |
LAMPE JOHN W.;WATSON PAUL S.;SLADE DAVID J.;PETERSON WARD M.;CREAN CHRISTOPHER S.;VITTITOW JASON L.;DECAMP JONATHAN BRYAN;PELZ NICHOLAS F.;INSPIRE PHARMACEUTICALS, INC. |
发明人 |
LAMPE JOHN W.;WATSON PAUL S.;SLADE DAVID J.;PETERSON WARD M.;CREAN CHRISTOPHER S.;VITTITOW JASON L.;DECAMP JONATHAN BRYAN;PELZ NICHOLAS F. |
分类号 |
C07D211/32;A01N43/40 |
主分类号 |
C07D211/32 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|