发明名称 |
Functional immunohistochemical cell cycle analysis as a prognostic indicator for cancer |
摘要 |
The present invention relates to a method of determining the presence of a retinoblastoma protein (Rb)-mediated cancerous or pre-cancerous condition in a sample of fixed cells that involves exposing the sample to an antibody that recognizes phosphorylation of serine on the retinoblastoma protein (pS-Rb), and identifying cells in the sample that are recognized by the antibody to pS-Rb, where the recognition of pS-Rb in the sample determines the presence of an Rb-mediated cancerous or pre-cancerous condition. The method also involves identifying the presence of specific cell cycle markers and positive and negative cell cycle regulators to assess the stage of disease progression in a cancer patient having an (Rb)-mediated cancer. The present invention also relates to methods of assessing the efficacy of cancer therapy for an Rb-mediated cancer, determining the mechanism of cell cycle progression in an Rb-mediated cancer, and identifying cells predisposed to developing an Rb-mediated cancerous condition. |
申请公布号 |
US8603763(B2) |
申请公布日期 |
2013.12.10 |
申请号 |
US20050547788 |
申请日期 |
2005.04.08 |
申请人 |
CHEN-KIANG SELINA;ELY SCOTT A.;DI LIBERTO MAURIZIO;CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
CHEN-KIANG SELINA;ELY SCOTT A.;DI LIBERTO MAURIZIO |
分类号 |
G01N33/574;G01N33/48 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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