发明名称 |
Individualized cancer therapy |
摘要 |
Methods for treating cancer that include (a) obtaining a specimen of cancer issue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue; (c) extracting total protein from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue; (e) identifying a group of proteins that are expressed in the cancer tissue at significantly different levels than in the normal tissue; (f) identifying one or more prioritized proteins from the group of proteins, which will serve as the target for an RNA interference molecule (RNAi), which, when provided to a patient, will reduce the expression level of the one or more prioritized proteins using both cleavage-dependent and cleavage-independent pathways of the RNA-induced silencing complex (RISC). |
申请公布号 |
US8603991(B2) |
申请公布日期 |
2013.12.10 |
申请号 |
US20060601431 |
申请日期 |
2006.11.17 |
申请人 |
SHANAHAN DAVID;NEMUNAITIS JOHN;SENZER NEIL;MAPLES PHILLIP;RAO DONALD;GRADALIS, INC. |
发明人 |
SHANAHAN DAVID;NEMUNAITIS JOHN;SENZER NEIL;MAPLES PHILLIP;RAO DONALD |
分类号 |
A61K31/70;C07H21/02;C07H21/04;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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