| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for selectively producing (+)-cis-sertraline represented by formula 1 and usable as an intermediate in the production of sertraline hydrochloride. SOLUTION: The method for producing the (+)-cis-sertraline represented by formula 1 includes a step for producing (+)-cis-sertraline (S)-(-)-2-pyrrolidone-5-carboxylate by reacting (±)-cis/trans-sertraline or (±)-cis-sertraline with (S)-(-)-2-pyrrolidone-5-carboxylic acid, and carrying out optical resolution thereof. COPYRIGHT: (C)2013,JPO&INPIT |
