NOVEL PYRROLE DERIVATIVE HAVING AS SUBSTITUTES UREIDE GROUP, AMINOCARBONYL GROUP AND BICYCLIC GROUP, OPTIONALLY SUBSTITUTED

摘要

FIELD: chemistry.SUBSTANCE: invention relates to novel pyrrole derivatives of the formula (1):or pharmaceutically acceptable salts thereof, where: Rdenotes H, halogen; Rdenotes an 8-10-member bicyclic hydrocarbon group, optionally substituted, or a bicyclic heterocyclic group consisting of one or two atoms selected from nitrogen, oxygen and sulphur and 5-9 carbon atoms, optionally substituted, where the optional substitute is halogen, lower alkyl, OH, lower alkoxy, oxo, NO, CN; Rdenotes H.EFFECT: compounds have inhibiting action of production of IL-6, which enables use thereof in a pharmaceutical composition and when treating a range of diseases.12 cl, 1 tbl, 10 ex