发明名称 |
A FUNCTION OF VALPROIC ACID IN SUICIDE GENE THERAPY |
摘要 |
The present invention relates to a suicide-gene cancer therapy by combining valproic acid (VPA) with stem cells expressing suicide genes such as herpes simplex virus type I thymidine kinase (HSV-TK). Glioma cells and the suicide gene-expressing stem cells treated with the valproic acid are cultured in combination with each other, thereby up-regulating the gap junction and enhancing the bystander effect, leading to an increase in the anticancer effect. |
申请公布号 |
KR20130133318(A) |
申请公布日期 |
2013.12.09 |
申请号 |
KR20120054470 |
申请日期 |
2012.05.22 |
申请人 |
CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATIONFOUNDATION |
发明人 |
JEUN, SIN SOO;RYU, CHUNG HEON |
分类号 |
A61K48/00;A61K31/19;A61P35/00 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|