发明名称 |
FORMULATION FOR ANTI-α4β7 ANTIBODY. |
摘要 |
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo. |
申请公布号 |
MX2013012724(A) |
申请公布日期 |
2013.12.06 |
申请号 |
MX20130012724 |
申请日期 |
2012.05.02 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
VAITHIANATHAN PALANIAPPAN;NOBEL T. TRUONG;CSANAD M. VARGA;WILLOW DILUZIO;JASON BROWN;IRVING H. FOX;CATHERINE SCHOLZ |
分类号 |
A61P1/00;A61K39/395;C07K16/28 |
主分类号 |
A61P1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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