发明名称 |
METHODS FOR PREPARING VESICLES AND FORMULATIONS PRODUCED THEREFROM |
摘要 |
The present disclosure provides methods for preparing vesicles. In one aspect, the methods involve providing a molten mixture of vesicle-forming lipids and adding the molten mixture of vesicle-forming lipids to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed, wherein in the step of adding the molten mixture of vesicle forming lipids is at a temperature of less than 120° C. In another aspect, the methods involve providing a molten mixture of vesicle-forming lipids and adding an aqueous solution comprising an antigen to the molten mixture of vesicle-forming lipids such that antigen-containing vesicles are formed, wherein the resulting mixture is placed under temperature-controlled conditions of less than 60° C. In yet another aspect, the methods involve providing a solution of vesicle forming lipids and adding the solution of vesicle-forming lipids to an aqueous solution comprising an antigen by injection such that antigen-containing vesicles are formed. |
申请公布号 |
US2013323280(A1) |
申请公布日期 |
2013.12.05 |
申请号 |
US201213979317 |
申请日期 |
2012.01.13 |
申请人 |
ANDERSON DAVID E.;PERRIE YVONNE;KIRCHMEIER MARC;WILKHU JITINDER SINGH;VARIATION BIOTECHNOLOGIES, INC. |
发明人 |
ANDERSON DAVID E.;PERRIE YVONNE;KIRCHMEIER MARC;WILKHU JITINDER SINGH |
分类号 |
A61K9/10;A61K39/00;A61K39/12;A61K39/145 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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