A defined peak region residing between about 3.2 and 3.4 ppm of a proton NMR spectrum of an in vitro biosample is electronically evaluated to determine a level of trimethylamine-N-oxide ("TMAO"). The biosamples may be any suitable biosamples including human serum with a normal biologic range of between about 1-50 µM or urine with a normal biologic range of between about 0-1000 µM.
申请公布号
WO2013180961(A1)
申请公布日期
2013.12.05
申请号
WO2013US41274
申请日期
2013.05.16
申请人
LIPOSCIENCE, INC.
发明人
OTVOS, JAMES D.;JEYARAJAH, ELIAS J.;WOLAK-DINSMORE, JUSTYNA E.;O'CONNELL, THOMAS M.;BENNETT, DENNIS W.;MATYUS, STEVEN P.