发明名称 |
Method to Identify Liver Toxicity Using Metabolite Profiles |
摘要 |
The present disclosure relates to a methodology that identifies the underlying mechanisms that lead to hepatotoxicity. This is done by using the alterations in cellular metabolite profiles obtained before and after therapy/drug treatment in combination with a model of liver metabolism. Subsequently, by using a covariance matrix adaptation followed by evolutionary selection, it compares the drug-induced metabolite profiles obtained experimentally with those generated using the in silico model, automatically shortlists potential parameters whose alterations could have produced the drug-treated metabolite profile. Values of these parameters are estimated by formulating an optimal control problem to minimize the differences between the model-generated metabolite values and experimentally observed data. The estimated parameters are given as an input to the homeostatic liver model and simulations are carried out, thereby the results providing a mechanistic explanation for the development of toxicity. |
申请公布号 |
US2013323767(A1) |
申请公布日期 |
2013.12.05 |
申请号 |
US201213984507 |
申请日期 |
2012.03.05 |
申请人 |
SUBRAMANIAN KALYANASUNDARAM;DAS SONALI;KUMAR RAJEEV;RAGHAVAN SOWMYA;SHAIK OSMAN SHAHI;CHAKRABARTI PARTHA PRATIM;KRISHNAKUMAR NARASIMHA MANDYAM;RAJESWARA NALINI;BHAT ANUPAMA RAJAN;STRAND LIFE SCIENCES PRIVATE LIMITED |
发明人 |
SUBRAMANIAN KALYANASUNDARAM;DAS SONALI;KUMAR RAJEEV;RAGHAVAN SOWMYA;SHAIK OSMAN SHAHI;CHAKRABARTI PARTHA PRATIM;KRISHNAKUMAR NARASIMHA MANDYAM;RAJESWARA NALINI;BHAT ANUPAMA RAJAN |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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