ASSAYS FOR THE IDENTIFICATION OF COMPOUNDS THAT MODULATE LIPID HOMEOSTASIS

摘要

The invention describes the role of regulated IRE 1 -dependent decay (RIDD) in modulating lipid homeostasis by degradation of particular lipid metabolism genes and the role of XBPl in modulating lipid homeostasis by regulating the transcriptional activation of particular lipogenic target genes. Methods for identifying modulators of lipid homeostasis based on modulation of IRE 1 -mediated RIDD of lipid metabolism genes or based on modulation of XBPl -mediated transcriptional regulation of lipogenic target genes are provided.