发明名称 |
CHIMERIC CD27 RECEPTORS FOR REDIRECTING T CELLS TO CD70-POSITIVE MALIGNANCIES |
摘要 |
The present invention concerns methods and compositions related to T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies. In aspects of the invention, T cells that are CD70-specific are employed. In particular aspects, there are T cells expressing a novel molecule that comprises the full-length CD70 receptor (CD27) fused to the zeta signaling domain of the T-cell receptor complex. Such T cells recognized CD70-positive tumor cells and have cytolytic activity against CD70-positive cancer cells. |
申请公布号 |
US2013323214(A1) |
申请公布日期 |
2013.12.05 |
申请号 |
US201113881772 |
申请日期 |
2011.10.27 |
申请人 |
GOTTSCHALK STEPHEN M.G.;SHAFFER DONALD R.;SPENCER DAVID M. |
发明人 |
GOTTSCHALK STEPHEN M.G.;SHAFFER DONALD R.;SPENCER DAVID M. |
分类号 |
A61K45/06;A61K35/14 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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