发明名称 |
RADIOLABELED BBN ANALOGS FOR PET IMAGING OF GASTRIN-RELEASING PEPTIDE RECEPTORS |
摘要 |
Radiolabeled bombesin (BBN) analogs that bind to the gastrin-releasing peptide receptor (GRPR) represent a topic of active investigation for the development of molecular probes for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) of prostate cancer (PCa). RM1 and AMBA have been identified as the two most promising BBN peptides for GRPR-targeted cancer imaging and therapy. In this study, to develop a clinically translatable BBN-based PET probe, we synthesized and evaluated 18F-AlF- and 64Cu-radiolabeled RM1 and AMBA analogs for their potential application in PET imaging of PCa. |
申请公布号 |
US2013323171(A1) |
申请公布日期 |
2013.12.05 |
申请号 |
US201313910318 |
申请日期 |
2013.06.05 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
CHENG ZHEN;LIU HONGGUANG;HU XIANG;LIU YANG |
分类号 |
C07K7/08;A61K51/08;G01N33/50 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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