发明名称 |
GLYCOGEN SYNTHASE KINASE-3 INHIBITORS |
摘要 |
Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are substrate-competitive inhibitors and have an amino acid sequence designed so as to bind to a defined binding site subunit in GSK-3. Also disclosed are GSK-3 substrate competitive inhibitors which bind to the defined binding site subunit in the enzyme. Also disclosed are mutants of GSK-3 and uses thereof for identifying a putative GSK-3 substrate competitive inhibitor. |
申请公布号 |
EP2668199(A2) |
申请公布日期 |
2013.12.04 |
申请号 |
EP20120704133 |
申请日期 |
2012.01.26 |
申请人 |
RAMOT AT TEL AVIV UNIVERSITY, LTD. |
发明人 |
ELDAR-FINKELMAN, HAGIT;LICHT-MURAVA, AVITAL;PLOTKIN, BATYA |
分类号 |
C07K7/06;A61K38/04;C07K7/08;C12N9/12;G01N33/68 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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