ANTIBODY-DRUG CONJUGATE FORMED THROUGH TRANSGLUTAMINASE AND USE THEREOF

摘要

The present invention relates to a method of producing an antibody-medicine corporate body comprising a step of making mutated antibody including glutamine and medicine including free amine group react under the existence of transglutaminase, to an antibody-medicine corporate body produced thereby, to an antibody-medicine corporate body in which medicine including mutated antibody and free amine group connected by isopeptide bond, to a composition for treating cancer including the antibody-medicine corporate body, to a method for treating cancer by using the antibody-medicine corporate body, and to a mutated body to which peptide including glutamine and antibody are connected.