NEW G-QUADRUPLEX DNA BINDERS, PROCESS FOR PREPARATION THEREOF AND THE USE OF THE SAME

摘要

The present invention relates to penoxazone-, triazine- and pyrazolopyrimidine-based c-myc inhibitor compositions and, more specifically, to a method for manufacturing the same and a pharmaceutical composition for preventing or treating cancer including the same as an active ingredients. The penoxazone-, triazine- and pyrazolopyrimidine-based chemical compounds of the present invention selectively stabilize the G-quadruplex structure of a c-myc promoter, thereby showing inhibiting effects of c-myc expression. This is a development of a new DNA targeting anti-cancer material beyond the limits of the existing DNA binding anti-cancer material, and excellent anti-cancer candidate material deducted the optimization of the chemical compounds of the present invention can be developed as an anticancer medicine for various cancers such as lung cancer, colorectal cancer, breast cancer, bladder cancer and leukemia, therefore is expected to be used in cancer treatment.