发明名称 |
RNASCOPE® HPV ASSAY FOR DETERMINING HPV STATUS IN HEAD AND NECK CANCERS AND CERVICAL LESIONS |
摘要 |
The present invention provides a method and a kit for determining whether a head and neck cancer is HPV-related. In one embodiment, an RNAscope® HPV assay was designed to detect the presence of E6/E7 mRNA of certain high-risk HPV subtypes related to head and neck cancer. The present invention also provides a method and a kit for determining whether a cervical lesion is a benign lesion or a cervical intraepithethial neoplasm lesion. The present invention further provides a method for determining the progression of cervical intraepithethial neoplasm based on the spatial pattern and levels of the E6/E7 mRNA of certain high-risk HPV subtypes. The present invention also provides a method for determining the risk of developing cervical cancer in a human diagnosed with cervical intraepithethial neoplasm based on presence and absence of the certain subgroups of high-risk HPV subtypes. |
申请公布号 |
EP2668290(A2) |
申请公布日期 |
2013.12.04 |
申请号 |
EP20120702157 |
申请日期 |
2012.01.27 |
申请人 |
ADVANCED CELL DIAGNOSTICS, INC. |
发明人 |
MA, XIAO-JUN;FLANAGAN, JOHN;LUO, YULING |
分类号 |
C12Q1/68;C12Q1/70 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|