发明名称 |
NOVEL 1-2-DIHYDROQUINOLINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY |
摘要 |
<p>An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R 1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R 2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R 3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R 4 and R 5 represent a hydrogen atom or the like; R 6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R 7 represents OR 8 , NR 8 R 9 , SR 8 , S (O) R 8 or S (O) 2 R 8 , wherein R 8 represents an aryl group, a heterocyclic group or the like and R 9 represents a hydrogen atom or the like.</p> |
申请公布号 |
EP1944290(B1) |
申请公布日期 |
2013.12.04 |
申请号 |
EP20060798171 |
申请日期 |
2006.09.14 |
申请人 |
SANTEN PHARMACEUTICAL CO., LTD. |
发明人 |
MATSUDA, MAMORU;MORI, TOSHIYUKI;KAWASHIMA, KENJI;NAGATSUKA, MASATO;KOBAYASHI, SACHIKO;YAMAMOTO, MINORU;KATO, MASATOMO;TAKAI, MIWA;ODA, TOMOKO |
分类号 |
C07D215/14;A61K31/47;A61K31/4709;A61P1/00;A61P3/04;A61P3/06;A61P3/10;A61P3/14;A61P5/48;A61P9/10;A61P9/12;A61P11/00;A61P11/06;A61P17/00;A61P19/02;A61P25/00;A61P25/18;A61P25/28;A61P27/02;A61P27/16 |
主分类号 |
C07D215/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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