发明名称 |
ANTI-KIT ANTIBODIES AND USES THEREOF |
摘要 |
Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein. |
申请公布号 |
EP2668210(A2) |
申请公布日期 |
2013.12.04 |
申请号 |
EP20120740001 |
申请日期 |
2012.01.25 |
申请人 |
KOLLTAN PHARMACEUTICALS, INC. |
发明人 |
HADARI, YARON;MANDEL-BAUSCH, ELIZABETH, M.;RADKE, SUSANNE;SCHLESSINGER, JOSEPH;SUZUKI, YOSHIHISA |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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