发明名称 |
THERAPEUTIC DLL4 BINDING PROTEINS |
摘要 |
DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis. |
申请公布号 |
EP2542582(A4) |
申请公布日期 |
2013.12.04 |
申请号 |
EP20110751147 |
申请日期 |
2011.02.28 |
申请人 |
ABBVIE INC. |
发明人 |
LI, YINGCHUN;GU, JIJIE, JAMES;MORGAN-LAPPE, SUSAN;CHEN, MINGJIU;HSIEH, CHUNG-MING |
分类号 |
C07K16/18 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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