Method for treating autoimmune diseases and compositions therefor

摘要

A method of cell-based therapy for treating an autoimmune disease is disclosed. The method is directed at stimulating leukocytes and/or dendritic cells to interrupt autoimmunity in a host. The method provides a Fcgamma receptor-specific complex or a complex which results in the co-crosslinking of Fcgamma-chains for treating the leukocytes and/or dendritic cells which are in turn used to elicit an autoimmune interruption response in a subject with an autoimmune disease. The Fcgamma receptor-specific complex and/or complex which results in the co-crosslinking of Fcgamma-chains is used to treat a biological sample comprising leukocytes and/or dendritic cells from a patient, and upon reintroducing said biological sample to the patient, the pre-treated dendritic cells illicit an autoimmune interruption response in vivo.