发明名称 |
Therapeutic approach to neurodegenerative disorders using a TFP5-peptide |
摘要 |
Disclosed herein are isolated peptides, pharmaceutical compositions and methods for use of such for treating subjects with a neurodegenerative disease, such as Alzheimer's. In an example, an isolated polypeptide includes a cyclin dependent kinase 5 (Cdk5) inhibitory domain that has at least 95% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, wherein the Cdk5 inhibitory domain is linked to a protein transduction domain. Methods of reducing or inhibiting one or more symptoms associated with a neurodegenerative disease by administering a therapeutically effective amount of a pharmaceutical composition including one or more disclosed peptides are also provided. |
申请公布号 |
US8597660(B2) |
申请公布日期 |
2013.12.03 |
申请号 |
US201113249003 |
申请日期 |
2011.09.29 |
申请人 |
PANT HARISH C.;ZHENG YA-LI;AMIN NIRANJANA D.;GRANT PHILIP;RUDRABHATLA PARVATHI;SHUKLA VARSHA;KESAVAPANY SASHI;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
PANT HARISH C.;ZHENG YA-LI;AMIN NIRANJANA D.;GRANT PHILIP;RUDRABHATLA PARVATHI;SHUKLA VARSHA;KESAVAPANY SASHI |
分类号 |
A61K39/385;A01N37/18;A61K38/00;A61K39/00 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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